Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Osteostatin 是甲状旁腺激素相关蛋白 (PTHrP) 107-111 片段，促进骨缺损动物模型的骨修复，防止炎症性关节炎的骨侵蚀，抑制骨胶原诱导的关节炎和破骨细胞吸收。Osteostatin 可用于免疫炎症研究。

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research.

Osteostatin (80 或 120 μg/kg；在疾病发作后每天皮下注射，持续 13 天) 降低关节炎的严重程度及软骨和骨降解。Animal Model:Collagen-induced arthritis in male DBA/1 miceDosage:80 or 120 μg/kg Administration:After the onset of disease s.c. every day for 13 days Result:Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes. Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.

Osteostatin (100，250，500 nM，7-9 天) 以浓度依赖的方式降低破骨细胞的分化。Osteostatin (100，250，500 nM，7 天) 降低组织蛋白酶 K、破骨细胞相关 Ig 样受体 (OSCAR) 和NFATc1 的 mRNA 水平。Osteostatin (100，250，500 nM，2 天) 抑制破骨细胞分化中主转录因子 NFATc1 的核转位。Osteostatin (0.1-100 nM, 2 天) 显著促进骨细胞 MC3T3-E1 的生长。Cell Differentiation Assay Cell Line:PBMCs are cultured with M-CSF and RANKL Concentration:100, 250 and 500 nM Incubation Time:7-9 days Result:Decreased the differentiation of osteoclasts in a concentration-dependent manner, but it does not modify the resorptive ability of mature osteoclasts.RT-PCR Cell Line:PBMCs are cultured with M-CSF and RANKL，Concentration:100, 250 and 500 nM Incubation Time:7 days Result:Decreased the mRNA levels of cathepsin K, osteoclast associated Ig-like receptor (OSCAR) and NFATc1. Immunofluorescence Cell Line:PBMCs are cultured with M-CSF and RANKL，Concentration:100, 250 and 500 nM Incubation Time:2 days Result:Inhibited the nuclear translocation of the master transcription factor in osteoclast differentiation NFATc1.Cell Proliferation Assay Cell Line:MC3T3-E1 cells，Concentration:0-100 nM Incubation Time:2 days Result:Significantly increased cell growth of MC3T3-E1 cells.

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Others

Other Targets

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138949-73-2

619.7

C27H41N9O8

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years